CJC-1295
Also known as CJC-1295 DAC, Modified GRF 1-29, Drug Affinity Complex
A synthetic growth hormone-releasing hormone (GHRH) analog with a Drug Affinity Complex that extends its half-life. CJC-1295 stimulates pulsatile GH release for improved body composition, sleep, and recovery. Often combined with Ipamorelin.
| Typical dose | 1000-2000 mcg (DAC) or 100 mcg (no DAC) |
|---|---|
| Frequency | Once or twice weekly (DAC) or nightly (no DAC) |
| Half-life | ~6-8 days (DAC), ~30 min (no DAC) |
| Cycle length | 8-16 weeks |
| Research level | extensive |
| Prescription required | Yes |
Mechanism of action
Binds to GHRH receptors on pituitary somatotrophs, stimulating cAMP-mediated GH synthesis and release. The DAC modification binds to albumin, extending the half-life from minutes to days.
What this means in practice
The single most important distinction is DAC versus no-DAC, and it changes everything about how the compound is used. The Drug Affinity Complex binds to albumin and stretches the half-life from minutes to days, which is why DAC versions are dosed weekly at 1000–2000 mcg while no-DAC (Modified GRF 1-29) is dosed at around 100 mcg several times daily. Confusing the two is the most common dosing error with this compound. It is almost always paired with a ghrelin agonist such as Ipamorelin, because the two act on separate receptors.
Reported side effects
- Water retention
- Tingling/numbness
- Flushing
- Increased hunger
Commonly stacked with
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