GHK-Cu

Also known as Copper Peptide GHK-Cu, Copper Tripeptide-1

Written by Matt Ward — I run these protocols myself and built Optim to track them.

A naturally occurring copper-binding tripeptide that declines with age. GHK-Cu promotes collagen synthesis, wound healing, hair growth, and has potent anti-inflammatory effects. Available as injectable, topical, and in skincare formulations.

Mechanism of action

Chelates copper ions to activate metalloproteinases for tissue remodeling, stimulates collagen/elastin synthesis via TGF-beta, attracts immune cells for repair, and resets gene expression toward a healthier state.

What this means in practice

GHK-Cu is the one compound here with a genuine mainstream footprint — copper peptides have been a skincare ingredient for years, which means most people meet it in a serum long before they encounter it as an injectable. The two routes serve different goals: topical for skin and hair, injectable for systemic collagen synthesis and wound healing. Levels decline substantially with age, which is the usual rationale for supplementing it. The copper is not incidental; the peptide's activity depends on chelating it.

Reported side effects

• Injection site irritation
• Mild redness (topical)

Commonly stacked with

This page is informational and summarises publicly available research. It is not medical advice, not a prescription, and not a recommendation to use any compound. Most compounds described here are not approved by the FDA for human use. Legal status varies by jurisdiction and is yours to determine. Talk to a qualified clinician before starting, stopping, or changing any protocol. For adults 18+. Optim does not sell, source, or recommend suppliers.