TB-500
Also known as Thymosin Beta-4, TB4
A synthetic version of Thymosin Beta-4, a naturally occurring peptide involved in tissue repair and cell migration. TB-500 promotes healing of muscles, tendons, ligaments, and skin. Often paired with BPC-157 for synergistic recovery.
| Typical dose | 2-5 mg |
|---|---|
| Frequency | Twice per week |
| Half-life | ~6 hours (effects last days) |
| Cycle length | 4-8 weeks loading, then monthly |
| Research level | moderate |
| Prescription required | No |
Mechanism of action
Sequesters G-actin monomers to promote cell migration, upregulates actin polymerization, reduces inflammation via NF-kB modulation, and enhances stem cell differentiation at injury sites.
What this means in practice
TB-500 is dosed unlike most peptides on this list. The ~6 hour half-life understates how it's actually used, because its effects persist well beyond clearance — which is why twice-weekly dosing is standard rather than daily. Protocols typically run a higher-frequency loading phase for the first month or two, then drop to a maintenance dose. It's the most common pairing with BPC-157, on the reasoning that the two act through different repair pathways.
Reported side effects
- Headache
- Temporary lethargy
- Injection site redness
Commonly stacked with
Track TB-500 properly
Log doses in one tap, watch the concentration curve update with real half-life math, and score outcomes to see whether it's working. Free, no account.
Get Optim on Google Play →This page is informational and summarises publicly available research. It is not medical advice, not a prescription, and not a recommendation to use any compound. Most compounds described here are not approved by the FDA for human use. Legal status varies by jurisdiction and is yours to determine. Talk to a qualified clinician before starting, stopping, or changing any protocol. For adults 18+. Optim does not sell, source, or recommend suppliers.